ZIKA VIRUS VACCINE - Perspective

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• Zika virus (ZIKV) is a deadly, mosquito-borne flavivirus transmitted through bite of infected female Aedes Zmosquito.
• It was first identified in monkeys from the Zika forest, near Lake Victoria, Uganda in 1947.
• The recent epidemic of ZIKV in America has revealed the catastrophic consequences of Zika infection.
• ZIKV infection in pregnant women can lead to congenital microcephaly in newborns, i.e., small sized head and brain characterised by incomplete development of cerebral cortex.
• It can also cause Guillain-Barre syndrome and other severe neurological disorders. Although, ZIKV is primarily transmitted through the bite of an infected Aedes mosquito. Other transmission modes such as sexual contact, blood transfusion and from mother to fetus are also possible.
• Currently, there is no FDA-approved vaccine or antiviral drug for ZIKV. Several efforts have been made to develop zika virus vaccine that are focussed on pre-membrane (prM) and envelope (E) protein.
• Recently scientists have developed a methyltransferase (MTase) defective rVSV (recombinant vesicular stomatitis virus) based ZIKV vaccine platform.
• These rVSV-based ZIKV vaccine candidates were highly attenuated but remained effective in triggering ZIKV-specific antibody and T cell immunity in mice and provided complete protection against ZIKV in mice.
• Although, important challenges remain for the clinical development, this rVSV-based vaccine is a promising candidate for ZIKV.

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NEET BIOLOGY

Biology for NEET

Biology Short Notes

Biology Test

CBSE/ BOARD Examination 

MANISH MEVADA

M.Sc, M.Phil, B.Ed

GUJARAT BIOLOGY NEET

NEET MATERIAL IN GUJARATI 

KNOWLEDGE ON THE WAY.